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The original goal of the staple was to get the peptide into the cell, but it turns out the staple can also enhance the binding and enhance the specificity, Keating says

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As science continues to unravel its secrets, the choice between these peptide powerhouses may become clearer

Sources: Conlon MA, Tomas FM, Owens PC, et al

Abd El-Twab SM, Hussein OE, Hozayen WG, Bin-Jumah M, Mahmoud AM (2019) Chicoric acid prevents methotrexate-induced kidney injury by suppressing NF-B/NLRP3 inflammasome activation and up-regulating Nrf2/ARE/HO-1 signaling